Selective Chemical Oxidation of Risperidone: A Straightforward and Cost-Effective Synthesis of Paliperidone

A very short and cost‐effective synthesis of the commercial drug paliperidone has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions. A very short and cost‐effective synthesis of the commercial drug paliperidone (1) h...

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Veröffentlicht in:	European Journal of Organic Chemistry 2011-04, Vol.2011 (12), p.2319-2325
Hauptverfasser:	Riva, Renata, Banfi, Luca, Castaldi, Graziano, Ghislieri, Diego, Malpezzi, Luciana, Musumeci, Francesca, Tufaro, Roberto, Rasparini, Marcello
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotics Biological and medical sciences Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Hydroxylation Medical sciences Medicinal chemistry Neuropharmacology Nitrogen heterocycles Organic chemistry Oxidation Pharmacology. Drug treatments Preparations and properties Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Synthesis design
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Beschreibung
Zusammenfassung:	A very short and cost‐effective synthesis of the commercial drug paliperidone has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions. A very short and cost‐effective synthesis of the commercial drug paliperidone (1) has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions.
ISSN:	1434-193X 1099-0690
DOI:	10.1002/ejoc.201001618