Catalytic Asymmetric Alkylation of Aldehydes by Using Trialkylboranes

Triethylborane can be used in the asymmetric alkylation of aldehydes by using a 3‐(3,5‐diphenylphenyl)‐H8‐BINOL‐derived titanium(IV) catalyst in the presence of an excess amount of titanium tetraisopropoxide. The reaction proceeds with a low catalyst loading (2 mol‐%), exhibiting high enantioselecti...

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Veröffentlicht in:	European Journal of Organic Chemistry 2008-09, Vol.2008 (26), p.4405-4407
Hauptverfasser:	Ukon, Takahiro, Harada, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Asymmetric catalysis asymmetric synthesis Boron Titanium
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Zusammenfassung:	Triethylborane can be used in the asymmetric alkylation of aldehydes by using a 3‐(3,5‐diphenylphenyl)‐H8‐BINOL‐derived titanium(IV) catalyst in the presence of an excess amount of titanium tetraisopropoxide. The reaction proceeds with a low catalyst loading (2 mol‐%), exhibiting high enantioselectivity for aromatic and unsaturated aldehydes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) Triethylborane can be used in the asymmetric alkylation of aldehydes by using a 3‐(3,5‐diphenylphenyl)‐H8‐BINOL‐derived titanium(IV) catalyst in the presence of an excess amount of titanium tetraisopropoxide.The reaction proceeds with a low catalyst loading (2 mol‐%), exhibiting high enantioselectivity for aromatic and unsaturated aldehydes.
ISSN:	1434-193X 1099-0690
DOI:	10.1002/ejoc.200800561