The Use of a Bifunctional Copper Catalyst in the Cross-Coupling Reactions of Aryl and Heteroaryl Halides with Terminal Alkynes

Copper‐catalyzed cross‐coupling reactions of aryl halides and heteroaryl halides with terminal alkynes were carried out in DMF at 110–130 °C to provide the corresponding coupling products in satisfactory‐to‐good yields by using inexpensive 8‐hydoxyquinoline as the ligand. Noteworthy is that the bifunctional copper catalyst was successfully applied in this alkynylation reaction for the first time.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) Copper‐catalyzed cross‐coupling reactions of aryl and heteroaryl halides with terminal alkynes were carried out in DMF at 110–130 °C to provide the corresponding coupling products in satisfactory‐to‐good yieldsby using inexpensive 8‐hydoxyquinoline (2) as the ligand. The bifunctional copper catalyst was successfully used in this alkynylation reaction for the first time.