A Ring-Closing Metathesis Pathway to Fluorovinyl-Containing Nitrogen Heterocyles

A Ring-Closing Metathesis Pathway to Fluorovinyl-Containing Nitrogen Heterocyles

The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring‐closing metathesis reaction involving fluoride‐substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted pi...

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Veröffentlicht in:European Journal of Organic Chemistry 2006-03, Vol.2006 (5), p.1166-1176
Hauptverfasser: De Matteis, Valeria, van Delft, Floris L., Tiebes, Jörg, Rutjes, Floris P. J. T.
Format: Artikel
Sprache:eng
Schlagworte:
Cyclic amino acids
Fluorinated heterocycles
Fluoroacrylates
Ring-closing metathesis
Vinyl fluoride
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Zusammenfassung:The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring‐closing metathesis reaction involving fluoride‐substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200500826