Highly Efficient CuBr-Catalyzed Cross-Dehydrogenative Coupling (CDC) between Tetrahydroisoquinolines and Activated Methylene Compounds

Highly Efficient CuBr-Catalyzed Cross-Dehydrogenative Coupling (CDC) between Tetrahydroisoquinolines and Activated Methylene Compounds

A novel and efficient C–C bond‐formation method was developed: the cross‐dehydrogenative coupling (CDC) reaction catalyzed by copper bromide in the presence of an oxidizing reagent, tBuOOH. The CDC reaction provides a simple and efficient catalytic method to construct β‐amino diesters and β‐dicyano...

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Veröffentlicht in:European Journal of Organic Chemistry 2005-08, Vol.2005 (15), p.3173-3176
Hauptverfasser: Li, Zhiping, Li, Chao-Jun
Format: Artikel
Sprache:eng
Schlagworte:
Amine
C-CN bond cleavage
C-H activation
Copper catalyst
Cross coupling
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Beschreibung
Zusammenfassung:A novel and efficient C–C bond‐formation method was developed: the cross‐dehydrogenative coupling (CDC) reaction catalyzed by copper bromide in the presence of an oxidizing reagent, tBuOOH. The CDC reaction provides a simple and efficient catalytic method to construct β‐amino diesters and β‐dicyano amines by a combination of two different sp3 C–H bonds followed by C–C bond formation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200500226