Synthesis of (ϵ‐ 13 C‐,ϵ‐ 15 N)‐Enriched L ‐Lysine − Establishing Schemes for the Preparation of All Possible 13 C and 15 N Isotopomers of L ‐Lysine, L ‐Ornithine, and L ‐Proline

In this paper we describe a simple synthetic strategy that, with the right rational adaptation, gives direct access to any 13 C/ 15 N isotopomer of L ‐glutamate, L ‐ornithine, L ‐proline, L ‐lysine, and L ‐α amino adipic acid. This strategy also allows access to nonproteinogenic amino acids like L ‐citrulline in high yields and optical purity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)