RGD-Porphyrin Conjugates: Synthesis and Potential Application in Photodynamic Therapy

RGD-Porphyrin Conjugates: Synthesis and Potential Application in Photodynamic Therapy

We report a convenient solid‐phase synthesis and characterisation of a new class of glycosylated porphyrins bearing the RGD tripeptide, designed for photodynamic cancer therapy. The photocytotoxicities of these compounds against the K562 leukemia cell line are also presented and compared to the effe...

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Veröffentlicht in:European journal of organic chemistry 2003-04, Vol.2003 (8), p.1486-1493
Hauptverfasser: Chaleix, Vincent, Sol, Vincent, Huang, Yi-Ming, Guilloton, Michel, Granet, Robert, Blais, Jean Claude, Krausz, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Glycosylation
Photodynamic therapy
Porphyrins
Solid-phase synthesis
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Zusammenfassung:We report a convenient solid‐phase synthesis and characterisation of a new class of glycosylated porphyrins bearing the RGD tripeptide, designed for photodynamic cancer therapy. The photocytotoxicities of these compounds against the K562 leukemia cell line are also presented and compared to the effect of Photofrin II®. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200390208