Novel DNA-Damaging Tropolone Derivatives from Goupia glabra

Novel DNA-Damaging Tropolone Derivatives from Goupia glabra

Two novel tropolone derivatives 1 and 2 have been isolated from Goupia glabra. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies. Compound 2 constitutes the first example isolated from a natural source of a Diels−Alder adduct between a tropolone and a naphthalene deri...

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Veröffentlicht in:European journal of organic chemistry 2003-11, Vol.2003 (21), p.4243-4247
Hauptverfasser: Mesa-Siverio, Dulce, Estévez-Braun, Ana, Ravelo, Ángel G., Murguia, Jose R., Rodríguez-Afonso, Abigail
Format: Artikel
Sprache:eng
Schlagworte:
Benzotropolone
Cycloadditions
DNA damage
Natural products
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Zusammenfassung:Two novel tropolone derivatives 1 and 2 have been isolated from Goupia glabra. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies. Compound 2 constitutes the first example isolated from a natural source of a Diels−Alder adduct between a tropolone and a naphthalene derivative. Compounds 1 and 2 exhibit significant toxicity towards a panel of DNA damage checkpoint defective yeast mutants, and behave as genotoxins, which highlights their potential to be used as anticancer drugs. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200300284