Synthesis of Differently Disubstituted 2,2′-Bipyridines by a Modified Negishi Cross-Coupling Reaction

Synthesis of Differently Disubstituted 2,2′-Bipyridines by a Modified Negishi Cross-Coupling Reaction

A general practical approach to a number of differently disubstituted 2,2′‐bipyridines from substituted 2‐bromo‐ and 2‐chloropyridines by application of modified Negishi cross‐coupling conditions has been developed. These 2,2′‐bipyridines carry versatile functional groups that can be elaborated furt...

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Veröffentlicht in:European journal of organic chemistry 2003-10, Vol.2003 (20), p.3948-3957
Hauptverfasser: Lützen, Arne, Hapke, Marko, Staats, Holger, Bunzen, Jens
Format: Artikel
Sprache:eng
Schlagworte:
2,2′‐Bipyridines
2′-Bipyridines
Biaryls
Cross-coupling
Negishi reaction
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Zusammenfassung:A general practical approach to a number of differently disubstituted 2,2′‐bipyridines from substituted 2‐bromo‐ and 2‐chloropyridines by application of modified Negishi cross‐coupling conditions has been developed. These 2,2′‐bipyridines carry versatile functional groups that can be elaborated further, as demonstrated for some examples. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200300192