The First, General, Highly Efficient Method for Preparing Tetrasubstituted Epoxides Using HOF·CH 3 CN
Tetrasubstituted epoxides, and especially electron‐depleted ones, generally are difficult to prepare. HOF·CH 3 CN complex, probably the best oxygen transfer agent known today, epoxidizes tetrasubstituted alkenes at 0 °C in a matter of minutes or less in excellent yields. HOF·CH 3 CN complex is very...
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| Veröffentlicht in: | European journal of organic chemistry 2003-05, Vol.2003 (10), p.1915-1917 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Tetrasubstituted epoxides, and especially electron‐depleted ones, generally are difficult to prepare. HOF·CH
3
CN complex, probably the best oxygen transfer agent known today, epoxidizes tetrasubstituted alkenes at 0 °C in a matter of minutes or less in excellent yields. HOF·CH
3
CN complex is very easy to prepare by bubbling diluted fluorine (commercial) through aqueous acetonitrile. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003) |
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| ISSN: | 1434-193X 1099-0690 |
| DOI: | 10.1002/ejoc.200300082 |