Solvent-Free Microwave-Assisted Efficient Synthesis of 4,4-Disubstituted 2-Oxazolines

Solvent-Free Microwave-Assisted Efficient Synthesis of 4,4-Disubstituted 2-Oxazolines

4,4‐Disubstituted 2‐oxazolines have been synthesized by a microwave‐promoted solvent‐free direct condensation of carboxylic acids and disubstituted β‐amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described here...

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Veröffentlicht in:European journal of organic chemistry 2003-11, Vol.2003 (22), p.4387-4391
Hauptverfasser: García-Tellado, Fernando, Loupy, André, Petit, Alain, Marrero-Terrero, Alma Leilani
Format: Artikel
Sprache:eng
Schlagworte:
Amino alcohols
Carboxylic acids
Microwaves
Nitrogen heterocycles
Zinc
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Zusammenfassung:4,4‐Disubstituted 2‐oxazolines have been synthesized by a microwave‐promoted solvent‐free direct condensation of carboxylic acids and disubstituted β‐amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200200469