Different β‐cell secretory phenotype in non‐obese compared to obese early type 2 diabetes

Background Type 2 diabetes (T2D) is characterized by impaired tissue sensitivity to insulin action (ie, insulin resistance) and impaired β‐cell insulin secretion. Because obesity contributes importantly to the development of insulin resistance, we sought to determine whether insulin secretory defects would predominate in non‐obese compared to obese T2D. Methods We measured β‐cell function and secretory capacity using the glucose‐potentiated arginine test in T2D subjects early in the disease course classified as non‐obese (BMI