Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b...

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Veröffentlicht in:Drug development research 1993-11, Vol.30 (3), p.143-146
Hauptverfasser: Anderson, Wayne K., Houston, D. Michael, Jarosinski, Mark A., Kinder Jr, Frederick R., Kode, Rao N., Van Roey, Patrick, Salerno, Jeffrey M.
Format: Artikel
Sprache:eng
Schlagworte:
anticancer
Antineoplastic agents
Biological and medical sciences
carmethizole
Chemotherapy
hydrolysis
Medical sciences
Pharmacology. Drug treatments
toxicity
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Zusammenfassung:The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. © 1993 wiley‐Liss, Inc.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.430300306