Triazolo antidepressants do not inhibit monoamine oxidase
The nontricyclic antidepressant trazodone and the related triazolo antidepressants nefazodone and etoperidone are monoamine uptake inhibitors. We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies....
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| Veröffentlicht in: | Drug development research 1988, Vol.12 (1), p.77-79 |
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| container_title | Drug development research |
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| creator | Hyslop, Deborah K. Allen, Lloyd E. Taylor, Duncan P. |
| description | The nontricyclic antidepressant trazodone and the related triazolo antidepressants nefazodone and etoperidone are monoamine uptake inhibitors. We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies. This suggests that the clinical use of trazodone, nefazodone, or etoperidone will not be associated with deleterious dietary interactions seen with monoamine oxidase inhibitor antidepressants. |
| doi_str_mv | 10.1002/ddr.430120108 |
| format | Article |
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We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies. This suggests that the clinical use of trazodone, nefazodone, or etoperidone will not be associated with deleterious dietary interactions seen with monoamine oxidase inhibitor antidepressants.</description><identifier>ISSN: 0272-4391</identifier><identifier>EISSN: 1098-2299</identifier><identifier>DOI: 10.1002/ddr.430120108</identifier><identifier>CODEN: DDREDK</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; etoperidone ; Medical sciences ; nefazodone ; Neuropharmacology ; nontricyclic antidepressant ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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Res</addtitle><description>The nontricyclic antidepressant trazodone and the related triazolo antidepressants nefazodone and etoperidone are monoamine uptake inhibitors. We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies. This suggests that the clinical use of trazodone, nefazodone, or etoperidone will not be associated with deleterious dietary interactions seen with monoamine oxidase inhibitor antidepressants.</description><subject>Biological and medical sciences</subject><subject>etoperidone</subject><subject>Medical sciences</subject><subject>nefazodone</subject><subject>Neuropharmacology</subject><subject>nontricyclic antidepressant</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>trazodone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hyslop, Deborah K.</creatorcontrib><creatorcontrib>Allen, Lloyd E.</creatorcontrib><creatorcontrib>Taylor, Duncan P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Drug development research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hyslop, Deborah K.</au><au>Allen, Lloyd E.</au><au>Taylor, Duncan P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triazolo antidepressants do not inhibit monoamine oxidase</atitle><jtitle>Drug development research</jtitle><addtitle>Drug Dev. 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| ispartof | Drug development research, 1988, Vol.12 (1), p.77-79 |
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| language | eng |
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| subjects | Biological and medical sciences etoperidone Medical sciences nefazodone Neuropharmacology nontricyclic antidepressant Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology trazodone |
| title | Triazolo antidepressants do not inhibit monoamine oxidase |
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