Triazolo antidepressants do not inhibit monoamine oxidase

The nontricyclic antidepressant trazodone and the related triazolo antidepressants nefazodone and etoperidone are monoamine uptake inhibitors. We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies....

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Veröffentlicht in:	Drug development research 1988, Vol.12 (1), p.77-79
Hauptverfasser:	Hyslop, Deborah K., Allen, Lloyd E., Taylor, Duncan P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences etoperidone Medical sciences nefazodone Neuropharmacology nontricyclic antidepressant Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology trazodone
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Zusammenfassung:	The nontricyclic antidepressant trazodone and the related triazolo antidepressants nefazodone and etoperidone are monoamine uptake inhibitors. We quantified the interaction of these compounds with monoamine oxidases in vitro and in vivo. All three compounds were devoid of activity in these studies. This suggests that the clinical use of trazodone, nefazodone, or etoperidone will not be associated with deleterious dietary interactions seen with monoamine oxidase inhibitor antidepressants.
ISSN:	0272-4391 1098-2299
DOI:	10.1002/ddr.430120108