Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa
Novel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator...
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| Veröffentlicht in: | Drug development research 2011-08, Vol.72 (5), p.405-415 |
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| creator | Li, Nian‐Guang Wang, Rong Shi, Zhi‐Hao Tang, Yu‐Ping Li, Bao‐Quan Wang, Zhen‐Jiang Song, Shu‐Lin Qian, Li‐Hua Wei, Li Yang, Jian‐Ping Yao, Li‐Juan Xi, Jun‐Zuan Xu, Jia Feng, Feng Qian, Da‐Wei Duan, Jin‐Ao |
| description | Novel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. Drug Dev Res 72: 405–415, 2011. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ddr.20442 |
| format | Article |
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Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. 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Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. Drug Dev Res 72: 405–415, 2011. © 2011 Wiley‐Liss, Inc.</description><subject>atherosclerosis</subject><subject>ferulic acid</subject><subject>nitric oxide donor</subject><subject>nitric oxide release</subject><issn>0272-4391</issn><issn>1098-2299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kE1OwzAQRi0EEqGw4Abeskg7dt0mXqKWP6miEoJ1ZHvs1igkxU5B2XEEzshJMIQtm_k00pun0UfIOYMxA-ATxDDmIAQ_IBkDWeacS3lIMuAFz8VUsmNyEuMzAGOiLDPyurTRbxqqGqSxb7ptWiNtHW3aN1vT-_XXxye2TRtSOhv2tTdUGY902-vgMVIV6a7tbNN5VSdLiuQIbTR1ml2iMew31CS_R9XZqE7JkVN1tGd_OSJP11ePi9t8tb65W1yucpNe47k1oKWbCWORc-BKawe2hFIwzVDgXEipNZdzQHCzEpGzQmlpoJDazQo-n47IxeA16ZsYrKt2wb-o0FcMqp-uqtRV9dtVYicD--5r2_8PVsvlw3DxDU32b6o</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Li, Nian‐Guang</creator><creator>Wang, Rong</creator><creator>Shi, Zhi‐Hao</creator><creator>Tang, Yu‐Ping</creator><creator>Li, Bao‐Quan</creator><creator>Wang, Zhen‐Jiang</creator><creator>Song, Shu‐Lin</creator><creator>Qian, Li‐Hua</creator><creator>Wei, Li</creator><creator>Yang, Jian‐Ping</creator><creator>Yao, Li‐Juan</creator><creator>Xi, Jun‐Zuan</creator><creator>Xu, Jia</creator><creator>Feng, Feng</creator><creator>Qian, Da‐Wei</creator><creator>Duan, Jin‐Ao</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201108</creationdate><title>Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa</title><author>Li, Nian‐Guang ; Wang, Rong ; Shi, Zhi‐Hao ; Tang, Yu‐Ping ; Li, Bao‐Quan ; Wang, Zhen‐Jiang ; Song, Shu‐Lin ; Qian, Li‐Hua ; Wei, Li ; Yang, Jian‐Ping ; Yao, Li‐Juan ; Xi, Jun‐Zuan ; Xu, Jia ; Feng, Feng ; Qian, Da‐Wei ; Duan, Jin‐Ao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1142-ec0b9f54ced2202abbf0e80841b1d4d6499bb2960d0f58dd217ab9c079bf57263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>atherosclerosis</topic><topic>ferulic acid</topic><topic>nitric oxide donor</topic><topic>nitric oxide release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Nian‐Guang</creatorcontrib><creatorcontrib>Wang, Rong</creatorcontrib><creatorcontrib>Shi, Zhi‐Hao</creatorcontrib><creatorcontrib>Tang, Yu‐Ping</creatorcontrib><creatorcontrib>Li, Bao‐Quan</creatorcontrib><creatorcontrib>Wang, Zhen‐Jiang</creatorcontrib><creatorcontrib>Song, Shu‐Lin</creatorcontrib><creatorcontrib>Qian, Li‐Hua</creatorcontrib><creatorcontrib>Wei, Li</creatorcontrib><creatorcontrib>Yang, Jian‐Ping</creatorcontrib><creatorcontrib>Yao, Li‐Juan</creatorcontrib><creatorcontrib>Xi, Jun‐Zuan</creatorcontrib><creatorcontrib>Xu, Jia</creatorcontrib><creatorcontrib>Feng, Feng</creatorcontrib><creatorcontrib>Qian, Da‐Wei</creatorcontrib><creatorcontrib>Duan, Jin‐Ao</creatorcontrib><collection>CrossRef</collection><jtitle>Drug development research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Nian‐Guang</au><au>Wang, Rong</au><au>Shi, Zhi‐Hao</au><au>Tang, Yu‐Ping</au><au>Li, Bao‐Quan</au><au>Wang, Zhen‐Jiang</au><au>Song, Shu‐Lin</au><au>Qian, Li‐Hua</au><au>Wei, Li</au><au>Yang, Jian‐Ping</au><au>Yao, Li‐Juan</au><au>Xi, Jun‐Zuan</au><au>Xu, Jia</au><au>Feng, Feng</au><au>Qian, Da‐Wei</au><au>Duan, Jin‐Ao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa</atitle><jtitle>Drug development research</jtitle><date>2011-08</date><risdate>2011</risdate><volume>72</volume><issue>5</issue><spage>405</spage><epage>415</epage><pages>405-415</pages><issn>0272-4391</issn><eissn>1098-2299</eissn><abstract>Novel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. Drug Dev Res 72: 405–415, 2011. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/ddr.20442</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0272-4391 |
| ispartof | Drug development research, 2011-08, Vol.72 (5), p.405-415 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1002_ddr_20442 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | atherosclerosis ferulic acid nitric oxide donor nitric oxide release |
| title | Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa |
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