Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa

Novel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator...

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Veröffentlicht in:Drug development research 2011-08, Vol.72 (5), p.405-415
Hauptverfasser: Li, Nian‐Guang, Wang, Rong, Shi, Zhi‐Hao, Tang, Yu‐Ping, Li, Bao‐Quan, Wang, Zhen‐Jiang, Song, Shu‐Lin, Qian, Li‐Hua, Wei, Li, Yang, Jian‐Ping, Yao, Li‐Juan, Xi, Jun‐Zuan, Xu, Jia, Feng, Feng, Qian, Da‐Wei, Duan, Jin‐Ao
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Sprache:eng
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Zusammenfassung:Novel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. Drug Dev Res 72: 405–415, 2011. © 2011 Wiley‐Liss, Inc.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.20442