False Hyperglycemies in Diabetic Patients Using Icodextrin in Peritoneal Dialysis

BACKGROUND Monitoring blood glucose is an important part of integral management of peritoneal dialysis (PD) patients with diabetes. Nowadays, several systems of glucometers are commercially available, and practically all are based on 3 enzymatic reactions. The two systems used most often are glucose oxidase (GOD) and glucose dehydrogenase using pyrroloquinolinequinone cofactor (GDH/PQQ). On the other hand, icodextrin (Extraneal) is an isosmotic PD solution containing glucose polymers. Accumulation in the systemic circulation of icodextrin metabolites may lead to a disparity between fi nger‐stick and formal blood glucose measurement. METHODS We analyzed the possible interference of icodextrin metabolites with various glucose assays in 9 diabetic patients undergoing PD using icodextrin. RESULTS The simple regression test showed a good association between central laboratory values and the Ascensia Breeze II (Bayer) glucometer:GOD (r = 0.928; p