Proton Pump Inhibitors Augment the Risk of Major Adverse Cardiovascular Events and End‐Stage Renal Disease in Patients With Acute Kidney Injury After Temporary Dialysis

Proton pump inhibitors (PPIs) have been reported to increase the risk of acute and chronic renal disease. However, the data are unclear in patients with acute kidney injury (AKI) requiring dialysis (AKI‐D) who are often candidates for PPIs. To investigate this important issue, we identified 26,052 A...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2020-06, Vol.107 (6), p.1434-1445
Hauptverfasser:	Tsai, I‐Jung, Lai, Tai‐Shuan, Shiao, Chih‐Chung, Huang, Tao‐Min, Wang, Chih‐Hsien, Tsao, Chun-Hao, Chen, Liang-Wen, Lin, Yen‐Hung, Chen, Likwang, Wu, Vin‐Cent, Chu, Tzong‐Shinn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - therapy Aged Aged, 80 and over Cardiovascular Diseases - epidemiology Databases, Factual Female Follow-Up Studies Humans Incidence Kidney Failure, Chronic - epidemiology Male Middle Aged Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - adverse effects Renal Dialysis Risk Factors Taiwan
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Zusammenfassung:	Proton pump inhibitors (PPIs) have been reported to increase the risk of acute and chronic renal disease. However, the data are unclear in patients with acute kidney injury (AKI) requiring dialysis (AKI‐D) who are often candidates for PPIs. To investigate this important issue, we identified 26,052 AKI‐D patients from Taiwan’s National Health Insurance Research Database weaning from dialysis. During a mean follow‐up period of 3.52 years, the PPI users had a higher incidence of end‐stage renal disease (ESRD) than the PPI nonusers (P
ISSN:	0009-9236 1532-6535
DOI:	10.1002/cpt.1762