Modulation of CYP 450 Activities in Patients With Type 2 Diabetes

We conducted a comprehensive in vivo study evaluating the influence of type 2 diabetes (T2D) on major cytochrome P450 ( CYP 450) activities. These activities were assessed in 38 T2D and 35 non‐T2D subjects after a single oral administration of a cocktail of probe drugs: 100 mg caffeine ( CYP 1A2), 100 mg bupropion ( CYP 2B6), 250 mg tolbutamide ( CYP 2C9), 20 mg omeprazole ( CYP 2C19), 30 mg dextromethorphan ( CYP 2D6), 2 mg midazolam ( CYP 3As), and 250 mg chlorzoxazone (alone; CYP 2E1). Mean metabolic activity for CYP 2C19, CYP 2B6, and CYP 3A was decreased in subjects with T2D by about 46%, 45%, and 38% ( P