C‐C Bond Formation: Synthesis of C5 Substituted Pyrimidine and C8 Substituted Purine Nucleosides Using Water Soluble Pd‐imidate Complex

The synthesis of a highly efficient, water soluble [Pd(Sacc)2(TPA)2] complex for C‐C bond formation is described. Additionally, application of the [Pd(Sacc)2(TPA)2] complex for Suzuki‐Miyaura arylation of all four nucleosides (5‐iodo‐2′‐deoxyuridine [5‐IdU], 5‐iodo‐2′‐deoxycytidine [5‐IdC], 8‐bromo‐2′‐deoxyadenosine, and 8‐bromo‐2′‐deoxyguanosine) with various aryl/heteroaryl boronic acids in plain water under milder conditions is demonstrated. © 2016 by John Wiley & Sons, Inc.