Front Cover: Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer (ChemPlusChem 5/2018)

Front Cover: Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer (ChemPlusChem 5/2018)

The front cover shows translocation of nuclear factor erythroid 2‐related factor 2 (Nrf2) enhancer to the nuclei that was induced by its novel enhancer: 1‐(4‐((3,4‐dihydroxybenzylidene)amino)phenyl)‐5‐oxopyrrolidine‐3‐carboxylic acid. This compound showed potent antioxidant properties through activa...

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Veröffentlicht in:ChemPlusChem (Weinheim, Germany) Germany), 2018-05, Vol.83 (5), p.317-317
Hauptverfasser: Kahremany, Shirin, Babaev, Ilana, Hasin, Pinhas, Tamir, Tigist Y., Ben‐Zur, Tali, Cohen, Guy, Jiang, Zhengyu, Weintraub, Sagiv, Offen, Daniel, Rahimipour, Shai, Major, M. Ben, Senderowitz, Hanoch, Gruzman, Arie
Format: Artikel
Sprache:eng
Schlagworte:
medicinal chemistry
Nrf2
oxidative stress
oxopyrrolidine derivatives
virtual screening
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Zusammenfassung:The front cover shows translocation of nuclear factor erythroid 2‐related factor 2 (Nrf2) enhancer to the nuclei that was induced by its novel enhancer: 1‐(4‐((3,4‐dihydroxybenzylidene)amino)phenyl)‐5‐oxopyrrolidine‐3‐carboxylic acid. This compound showed potent antioxidant properties through activation of genes related to antioxidative cellular response. Details are given in the Full Paper by Arie Gruzman and co‐workers on page 320 in Issue 5, 2018 (DOI: 10.1002/cplu.201700539).
ISSN:2192-6506
2192-6506
DOI:10.1002/cplu.201800156