Front Cover: Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (ChemMedChem 20/2024)
The newly developed NanoBRET assay platform allows the detection of intracellular ligand binding to the chemokine receptors CCR6 and CXCR1, enables equilibrium as well as kinetic binding studies in a cell‐free and cellular environment, provides further evidence for the existence of a druggable IABS...
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| Veröffentlicht in: | ChemMedChem 2024-10, Vol.19 (20), p.n/a |
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| creator | Huber, Max E. Wurnig, Silas L. Moumbock, Aurélien F. A. Toy, Lara Kostenis, Evi Alonso Bartolomé, Ana Szpakowska, Martyna Chevigné, Andy Günther, Stefan Hansen, Finn K. Schiedel, Matthias |
| description | The newly developed NanoBRET assay platform allows the detection of intracellular ligand binding to the chemokine receptors CCR6 and CXCR1, enables equilibrium as well as kinetic binding studies in a cell‐free and cellular environment, provides further evidence for the existence of a druggable IABS at CCR6 and CXCR1, and allows mapping of CCR6 and CXCR1 ligands to distinct binding sites of these receptors. More details can be found in article 10.1002/cmdc.202400284 by Finn K. Hansen, Matthias Schiedel, and co‐workers. |
| doi_str_mv | 10.1002/cmdc.202482001 |
| format | Article |
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| source | Wiley Online Library Journals Frontfile Complete |
| title | Front Cover: Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (ChemMedChem 20/2024) |
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