Front Cover: Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (ChemMedChem 20/2024)

Front Cover: Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (ChemMedChem 20/2024)

The newly developed NanoBRET assay platform allows the detection of intracellular ligand binding to the chemokine receptors CCR6 and CXCR1, enables equilibrium as well as kinetic binding studies in a cell‐free and cellular environment, provides further evidence for the existence of a druggable IABS...

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Veröffentlicht in:ChemMedChem 2024-10, Vol.19 (20), p.n/a
Hauptverfasser: Huber, Max E., Wurnig, Silas L., Moumbock, Aurélien F. A., Toy, Lara, Kostenis, Evi, Alonso Bartolomé, Ana, Szpakowska, Martyna, Chevigné, Andy, Günther, Stefan, Hansen, Finn K., Schiedel, Matthias
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Sprache:eng
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Zusammenfassung:The newly developed NanoBRET assay platform allows the detection of intracellular ligand binding to the chemokine receptors CCR6 and CXCR1, enables equilibrium as well as kinetic binding studies in a cell‐free and cellular environment, provides further evidence for the existence of a druggable IABS at CCR6 and CXCR1, and allows mapping of CCR6 and CXCR1 ligands to distinct binding sites of these receptors. More details can be found in article 10.1002/cmdc.202400284 by Finn K. Hansen, Matthias Schiedel, and co‐workers.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202482001