Front Cover: Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH (ChemMedChem 11/2023)

The Front Cover shows the design of a potent LpxH inhibitor by attaching an acyl hydroxamate moiety that chelates the active site dimanganese cluster. The overall shape of the inhibitor resembles a dragon reaching out to claw the pearl. The dragon art was created/hand‐drawn by Julia Zhou, Durham Aca...

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Veröffentlicht in:ChemMedChem 2023-06, Vol.18 (11), p.n/a
Hauptverfasser: Kwak, Seung‐Hwa, Skyler Cochrane, C., Cho, Jae, Dome, Patrick A., Ennis, Amanda F., Kim, Jea Hyun, Zhou, Pei, Hong, Jiyong
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container_end_page n/a
container_issue 11
container_start_page
container_title ChemMedChem
container_volume 18
creator Kwak, Seung‐Hwa
Skyler Cochrane, C.
Cho, Jae
Dome, Patrick A.
Ennis, Amanda F.
Kim, Jea Hyun
Zhou, Pei
Hong, Jiyong
description The Front Cover shows the design of a potent LpxH inhibitor by attaching an acyl hydroxamate moiety that chelates the active site dimanganese cluster. The overall shape of the inhibitor resembles a dragon reaching out to claw the pearl. The dragon art was created/hand‐drawn by Julia Zhou, Durham Academy Middle School. More information can be found in the Research Article by Seung‐Hwa Kwak, C. Skyler Cochrane, Pei Zhou, Jiyong Hong et al.
doi_str_mv 10.1002/cmdc.202300283
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source Wiley Online Library Journals Frontfile Complete
subjects Antibiotics
Calcineurin-like phosphoesterase
Dimanganese clusters
Gram-negative bacteria
Lipid A
LpxH
title Front Cover: Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH (ChemMedChem 11/2023)
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