Front Cover: Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH (ChemMedChem 11/2023)
The Front Cover shows the design of a potent LpxH inhibitor by attaching an acyl hydroxamate moiety that chelates the active site dimanganese cluster. The overall shape of the inhibitor resembles a dragon reaching out to claw the pearl. The dragon art was created/hand‐drawn by Julia Zhou, Durham Aca...
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Veröffentlicht in: | ChemMedChem 2023-06, Vol.18 (11), p.n/a |
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creator | Kwak, Seung‐Hwa Skyler Cochrane, C. Cho, Jae Dome, Patrick A. Ennis, Amanda F. Kim, Jea Hyun Zhou, Pei Hong, Jiyong |
description | The Front Cover shows the design of a potent LpxH inhibitor by attaching an acyl hydroxamate moiety that chelates the active site dimanganese cluster. The overall shape of the inhibitor resembles a dragon reaching out to claw the pearl. The dragon art was created/hand‐drawn by Julia Zhou, Durham Academy Middle School. More information can be found in the Research Article by Seung‐Hwa Kwak, C. Skyler Cochrane, Pei Zhou, Jiyong Hong et al. |
doi_str_mv | 10.1002/cmdc.202300283 |
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source | Wiley Online Library Journals Frontfile Complete |
subjects | Antibiotics Calcineurin-like phosphoesterase Dimanganese clusters Gram-negative bacteria Lipid A LpxH |
title | Front Cover: Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH (ChemMedChem 11/2023) |
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