Front Cover: Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH (ChemMedChem 11/2023)

Front Cover: Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH (ChemMedChem 11/2023)

The Front Cover shows the design of a potent LpxH inhibitor by attaching an acyl hydroxamate moiety that chelates the active site dimanganese cluster. The overall shape of the inhibitor resembles a dragon reaching out to claw the pearl. The dragon art was created/hand‐drawn by Julia Zhou, Durham Aca...

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Veröffentlicht in:ChemMedChem 2023-06, Vol.18 (11), p.n/a
Hauptverfasser: Kwak, Seung‐Hwa, Skyler Cochrane, C., Cho, Jae, Dome, Patrick A., Ennis, Amanda F., Kim, Jea Hyun, Zhou, Pei, Hong, Jiyong
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Calcineurin-like phosphoesterase
Dimanganese clusters
Gram-negative bacteria
Lipid A
LpxH
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Zusammenfassung:The Front Cover shows the design of a potent LpxH inhibitor by attaching an acyl hydroxamate moiety that chelates the active site dimanganese cluster. The overall shape of the inhibitor resembles a dragon reaching out to claw the pearl. The dragon art was created/hand‐drawn by Julia Zhou, Durham Academy Middle School. More information can be found in the Research Article by Seung‐Hwa Kwak, C. Skyler Cochrane, Pei Zhou, Jiyong Hong et al.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202300283