Front Cover: Facile, Single‐Step Synthesis of a Series of D‐Ring Ethisterones Substituted with 1,4‐1,2,3‐Triazoles: Preliminary Evaluation of Cytotoxic Activities (ChemMedChem 8/2023)
The Front Cover shows a graphic description of the facile, single‐step syntheses of a series of ethisterone 1,4,1,2,3‐triazole derivatives (X=H, F, Cl, Br, I, O‐Ph‐4‐CH3) with promising anticancer activities. This is complemented by a DNA‐docking‐simulation graphically showing one of these compounds...
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| Veröffentlicht in: | ChemMedChem 2023-04, Vol.18 (8), p.n/a |
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| creator | Canseco‐González, Daniel Rodríguez‐Victoria, Isaac Apan‐Ramírez, Teresa Viviano‐Posadas, Alejandro O. Serrano‐García, Juan S. Arenaza‐Corona, Antonino Orjuela, Adrian L. Alí‐Torres, Jorge Dorazco‐González, Alejandro Morales‐Morales, David |
| description | The Front Cover shows a graphic description of the facile, single‐step syntheses of a series of ethisterone 1,4,1,2,3‐triazole derivatives (X=H, F, Cl, Br, I, O‐Ph‐4‐CH3) with promising anticancer activities. This is complemented by a DNA‐docking‐simulation graphically showing one of these compounds interacting with DNA through crosslink intrastrand π‐alkyl like interactions. Finally, the cover also illustrates the cytotoxic effect on leukemia cells (violet) (K562) from blood where the best compound of the series performed better. Cover design by Dr. Daniel Canseco‐González and Prof. David Morales‐Morales. More information can be found in the Research Article by Daniel Canseco‐González, Alejandro Dorazco‐González, David Morales‐Morales et al. |
| doi_str_mv | 10.1002/cmdc.202300190 |
| format | Article |
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This is complemented by a DNA‐docking‐simulation graphically showing one of these compounds interacting with DNA through crosslink intrastrand π‐alkyl like interactions. Finally, the cover also illustrates the cytotoxic effect on leukemia cells (violet) (K562) from blood where the best compound of the series performed better. Cover design by Dr. Daniel Canseco‐González and Prof. David Morales‐Morales. 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This is complemented by a DNA‐docking‐simulation graphically showing one of these compounds interacting with DNA through crosslink intrastrand π‐alkyl like interactions. Finally, the cover also illustrates the cytotoxic effect on leukemia cells (violet) (K562) from blood where the best compound of the series performed better. Cover design by Dr. Daniel Canseco‐González and Prof. David Morales‐Morales. 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| source | Wiley-Blackwell Journals |
| subjects | 1-4,1,2,3-triazoles anticancer agents Atom economy click chemistry (CuAAC) DNA-docking simulation medicinal chemistry steroids |
| title | Front Cover: Facile, Single‐Step Synthesis of a Series of D‐Ring Ethisterones Substituted with 1,4‐1,2,3‐Triazoles: Preliminary Evaluation of Cytotoxic Activities (ChemMedChem 8/2023) |
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