Cover Feature: Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity (ChemMedChem 3/2020)

The Cover Feature shows a representative DNA gyrase B (GyrB) inhibitor/ciprofloxacin hybrid that penetrates into Escherichia coli and displays antibacterial activity. The observed antibacterial activity of these hybrid molecules is mainly due to interaction with GyrA and/or ParC and not with the GyrB subunit, because inhibition of GyrB by the presented hybrids, although present, is not strong enough to provide a substantial contribution to the observed antibacterial activity. More information can be found in the Communication by Danijel Kikelj et al. on page 265 in Issue 3, 2020 (DOI: 10.1002/cmdc.201900607).