Front Cover: Structure‐Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases (ChemMedChem 21/2019)

The Front Cover highlights the modus operandi of the structure‐based screening of the described tetrazole hydrazide compounds vs. human histone methyltransferase (KDM4D). The compounds were soaked one by one into the protein crystals, and the corresponding structures revealed the binding of the receptive compounds in the protein's active site. Both hydrazide and tetrazole warheads were identified as strong binding motifs. The structural information on the binding of the compounds will form the basis for further compound development towards KDM4D inhibitor identification. More information can be found in the Full Paper by Manfred S. Weiss et al. on page 1828 in Issue 21, 2019 (DOI: 10.1002/cmdc.201900441).