Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)benzenesulfonamide Derivatives and Their Antitumor Mechanisms

Breaking the cycle: A series of N‐(2‐arylindol‐7‐yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone‐resistant prostate cancer PC‐3 cells, induced G2/M‐phase arrest, and induced apoptosis through a caspase‐dependent path...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2010-09, Vol.5 (9), p.1489-1497
Hauptverfasser:	Chiou, Chun-Tang, Chen, Grace Shiahuy, Chen, Meng-Ling, Li, Huoming, Shi, Lei, Huang, Xiang-Hong, Dai, Wei-Ming, Chern, Ji-Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	antimitotic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity apoptosis Benzenesulfonamides Cell Division Cell Line, Tumor cytotoxicity Drug Screening Assays, Antitumor G2 Phase Humans Indoles - chemical synthesis Indoles - chemistry Indoles - toxicity Male microtubules Microtubules - chemistry Microtubules - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - toxicity Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Breaking the cycle: A series of N‐(2‐arylindol‐7‐yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone‐resistant prostate cancer PC‐3 cells, induced G2/M‐phase arrest, and induced apoptosis through a caspase‐dependent pathway.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.201000228