A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells
A phosphine‐coordinated gold(I) thiosugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF‐7 cells.
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| Veröffentlicht in: | ChemMedChem 2008-11, Vol.3 (11), p.1667-1670 |
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| container_end_page | 1670 |
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| container_issue | 11 |
| container_start_page | 1667 |
| container_title | ChemMedChem |
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| creator | Viry, Elodie Battaglia, Eric Deborde, Valérie Müller, Tobias Réau, Régis Davioud-Charvet, Elisabeth Bagrel, Denyse |
| description | A phosphine‐coordinated gold(I) thiosugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF‐7 cells. |
| doi_str_mv | 10.1002/cmdc.200800210 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1860-7179 |
| ispartof | ChemMedChem, 2008-11, Vol.3 (11), p.1667-1670 |
| issn | 1860-7179 1860-7187 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_cmdc_200800210 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology antitumor agents Catalytic Domain Cell Cycle Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Flow Cytometry - methods gold Gold - chemistry Humans inhibitors Inhibitory Concentration 50 Models, Chemical Oxidation-Reduction oxidoreductases Oxidoreductases - chemistry thioredoxin reductase Thioredoxin-Disulfide Reductase - antagonists & inhibitors Thioredoxin-Disulfide Reductase - chemistry |
| title | A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells |
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