A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells

A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells

A phosphine‐coordinated gold(I) thiosugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF‐7 cells.

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Bibliographische Detailangaben
Veröffentlicht in:ChemMedChem 2008-11, Vol.3 (11), p.1667-1670
Hauptverfasser: Viry, Elodie, Battaglia, Eric, Deborde, Valérie, Müller, Tobias, Réau, Régis, Davioud-Charvet, Elisabeth, Bagrel, Denyse
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
antitumor agents
Catalytic Domain
Cell Cycle
Cell Line, Tumor
Chemistry, Pharmaceutical - methods
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Flow Cytometry - methods
gold
Gold - chemistry
Humans
inhibitors
Inhibitory Concentration 50
Models, Chemical
Oxidation-Reduction
oxidoreductases
Oxidoreductases - chemistry
thioredoxin reductase
Thioredoxin-Disulfide Reductase - antagonists & inhibitors
Thioredoxin-Disulfide Reductase - chemistry
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Beschreibung
Zusammenfassung:A phosphine‐coordinated gold(I) thiosugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF‐7 cells.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200800210