The Presence of a Ferrocenyl Unit on an Estrogenic Molecule is Not Always Sufficient to Generate in vitro Cytotoxicity

We recently reported the dual (antihormonal and cytotoxic) functionality of ferrocifens, which are organometallic complexes derived from hydroxytamoxifen, the standard molecule in the treatment of hormone‐dependent breast cancers. To test the hypothesis that the presence of a ferrocenyl substituent...

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Veröffentlicht in:	ChemMedChem 2006-11, Vol.1 (11), p.1275-1281
Hauptverfasser:	Vessières, Anne, Spera, Daniela, Top, Siden, Misterkiewicz, Boguslav, Heldt, Jan-Martin, Hillard, Elizabeth, Huché, Michel, Plamont, Marie-Aude, Napolitano, Elio, Fiaschi, Rita, Jaouen, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology antitumor agents bioorganometallic chemistry breast cancer Breast Neoplasms - pathology Cell Line, Tumor Cell Survival - drug effects Electrochemistry Estrogens - chemistry Ferrous Compounds - chemistry Humans iron Metallocenes Models, Molecular Receptors, Estrogen - metabolism steroids
Online-Zugang:	Volltext
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