Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids

An efficient method for Cu-catalyzed decarboxylative trifluoromethylation offl-ketoacids to achieve a-trifluoro- methyl ketones was developed. A wide variety of synthetically useful α-trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method al...

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Veröffentlicht in:	Chinese journal of chemistry 2017-11, Vol.35 (11), p.1665-1668
Hauptverfasser:	Xu, Xiaolan, Chen, Huanhuan, He, Jianbo, Xu, Huajian
Format:	Artikel
Sprache:	eng
Schlagworte:	decarboxylative trifluoromethylation α‐trifluoromethyl ketones β‐ketoacids
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Zusammenfassung:	An efficient method for Cu-catalyzed decarboxylative trifluoromethylation offl-ketoacids to achieve a-trifluoro- methyl ketones was developed. A wide variety of synthetically useful α-trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional-group compatibility.
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201700271