Synthesis of Functionalized γ-Lactams via Copper-Catalyzed Intramolecular C-Vinylation of Activated Methylene Compounds
With the catalysis of CuI/3,4,7,8‐tetramethyl‐1,10‐phenanthroline, a number of N‐(2‐iodoallyl)‐2‐(ethoxycarbonyl)alkanamides underwent efficient intramolecular C‐vinylation in THF at 50°C leading to the synthesis of functionalized γ‐lactams in 61% –99% yields.
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| Veröffentlicht in: | Chinese journal of chemistry 2010-09, Vol.28 (9), p.1660-1664 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | With the catalysis of CuI/3,4,7,8‐tetramethyl‐1,10‐phenanthroline, a number of N‐(2‐iodoallyl)‐2‐(ethoxycarbonyl)alkanamides underwent efficient intramolecular C‐vinylation in THF at 50°C leading to the synthesis of functionalized γ‐lactams in 61% –99% yields. |
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| ISSN: | 1001-604X 1614-7065 |
| DOI: | 10.1002/cjoc.201090281 |