Synthesis and Structural Studies of 1-Deoxybaccatin VI Derivatives

Synthesis and crystal structures of 1‐deoxybaccatin VI derivatives, and the influence of C(9), C(10), and C(13) substituents of the tetracyclic moiety on molecular conformations were investigated. Comparison of conformations of 1‐deoxybaccatin VI derivatives reveals subtle conformational variations in the tetracyclic ring system due to deacetylation at C(10) and C(13), and 9,10‐acetonide. Additionally, C(2)‐benzoyl group exhibits an unexpected conformational flexibility in 1‐deoxybaccatin VI derivatives, which may be relevant to the bioactivity of taxanes.