Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2＇,1＇：5,1]pyrazolo[4,3-d]pyrimidin-4-one Derivatives

Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2＇,1＇：5,1]pyrazolo[4,3-d]pyrimidin-4-one Derivatives

Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.

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Bibliographische Detailangaben
Veröffentlicht in:Chinese journal of chemistry 2007-02, Vol.25 (2), p.241-245
1. Verfasser: 田广辉 夏广新 金薇西 陈新建 赖顺安 韦亚兵 嵇汝运 沈敬山
Format: Artikel
Sprache:eng
Schlagworte:
PDE5 inhibitor
pyridopyrazolopyrimidinone
sildenafil
化合物
化学活性
合成方法
衍生物
高分子化学
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Zusammenfassung:Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.200790048