Design and Synthesis of Novel Peptide Nucleic Acid Monomers

Design and Synthesis of Novel Peptide Nucleic Acid Monomers

All of the four nucleobases in DNA have replaced the 4‐hydroxy group of N‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy] tetrahydropyrrole acetic acid methyl ester with cis ‐stereochemistry. An efficient route for the synthesis of N‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy]‐tetrahyd...

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Veröffentlicht in:Chinese journal of chemistry 2001-03, Vol.19 (3), p.276-281
Hauptverfasser: Bai, Jin-Quan, Li, Ying, Liu, Ke-Liang
Format: Artikel
Sprache:eng
Schlagworte:
design
Oligonucleotide
peptide nucleic acids
synthesis
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Beschreibung
Zusammenfassung:All of the four nucleobases in DNA have replaced the 4‐hydroxy group of N‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy] tetrahydropyrrole acetic acid methyl ester with cis ‐stereochemistry. An efficient route for the synthesis of N‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy]‐tetrahydropyrrole acetic acid methyl ester has been developed. Starting with this intermediate, the protected monomers were synthesized by the Mitsunobu reaction or via its tosylate.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.20010190313