5-Fluorouracil derivatives XXIII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils having aromatic ring

5-Fluorouracil derivatives XXIII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils having aromatic ring

In order to get good antitumor agents especially better than 5‐fluorouracil, tegafur and l‐hexylcarbamoyl‐5‐fluorouracil (HCFU), fourty nine 1‐carbamoyl‐5‐fluorouracil having aromatic ring were synthesized from 5‐fluorouracil and isocyanates or mines. Antitumor activity was tested in the L1210 tumor...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chinese journal of chemistry 1998-03, Vol.16 (2), p.171-177
Hauptverfasser: Shoichiro, Ozaki, Xiang-Zheng, Kong, Yutaka, Watanabe, Tomonori, Hoshiko, Tomio, Ogasawara, Takao, Ueno, Uiroyuki, Furukawa, Masaaki, Iigo, Akio, Hoshi
Format: Artikel
Sprache:eng
Schlagworte:
1-(p-iso-propylbenzyl)-5-fluorouracil
Antitumor agent
aromatic carbamoyl-5-fluorouracil
l-(p-methoxybenzyl)-5-fluorouracil
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In order to get good antitumor agents especially better than 5‐fluorouracil, tegafur and l‐hexylcarbamoyl‐5‐fluorouracil (HCFU), fourty nine 1‐carbamoyl‐5‐fluorouracil having aromatic ring were synthesized from 5‐fluorouracil and isocyanates or mines. Antitumor activity was tested in the L1210 tumor system, and 5 compounds gave better value of therapeutic ratio than 5‐fluorouracil, tegafur, HCFU. 1‐(4‐Methoxybenzylcarbamoyl)‐5‐fluorouracil gave the best result.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.19980160210