ChemInform Abstract: Construction of an All-Carbon Quaternary Stereocenter by Organocatalytic Enantioselective α-Functionalization of α-Substituted β-Ketocarbonyls with Electron Deficient Vinylarenes

The enantioselective reaction of ketones (II) and (VI) with vinylarenes (I) gives rise to desired dicarbonyl compounds (III) and (VII), which are readily converted into chiral pyrazolones (V) and (VIII), respectively.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemInform 2015-12, Vol.46 (48), p.no-no
Hauptverfasser:	Liu, Shizhou, Tong, Mengchao, Yu, Yang, Xie, Hexin, Li, Hao, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	annulation reactions C-C bond formation diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) enantioselective syntheses (incl. cis/trans-isomerism) organocatalysis pyrazole derivatives ring closure reactions ring closure reactions, annulation reactions
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Beschreibung
Zusammenfassung:	The enantioselective reaction of ketones (II) and (VI) with vinylarenes (I) gives rise to desired dicarbonyl compounds (III) and (VII), which are readily converted into chiral pyrazolones (V) and (VIII), respectively.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201548140