ChemInform Abstract: The β-Silyl Effect on the Memory of Chirality in Friedel-Crafts Alkylation Using Chiral α-Aryl Alcohols

It is found that the retention of the configuration of the hydroxyl group as a leaving group bases on the conformational stability of the carbocation intermediate supported by a flexible silyl substituent.

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Veröffentlicht in:	ChemInform 2015-11, Vol.46 (44), p.no-no
Hauptverfasser:	Nokami, Toshiki, Yamane, Yu, Oshitani, Shunsuke, Kobayashi, Jun-ka, Matsui, Shin-ichiro, Nishihara, Takashi, Uno, Hidemitsu, Hayase, Shuichi, Itoh, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) enantioselective syntheses (incl. cis/trans-isomerism) indole derivatives indole derivatives, isoindole derivatives isoindole derivatives organo-silicon compounds
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Beschreibung
Zusammenfassung:	It is found that the retention of the configuration of the hydroxyl group as a leaving group bases on the conformational stability of the carbocation intermediate supported by a flexible silyl substituent.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201544204