ChemInform Abstract: Synthesis of 2-Aryl-3-(2-cyanoethyl)aziridines and Their Chemical and Enzymatic Hydrolysis Towards γ-Lactams and γ-Lactones

The title compounds (IV) are transformed into variable mixtures of 4‐[aryl(alkylamino)methyl]butyrolactones and 5‐[aryl(hydroxy)methyl]pyrrolidin‐2‐ones by KOH‐mediated hydrolysis of the cyano group, followed by ring expansion.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemInform 2015-07, Vol.46 (27), p.no-no
Hauptverfasser:	Mollet, Karen, Decuyper, Lena, Vander Meeren, Saskia, Piens, Nicola, De Winter, Karel, Desmet, Tom, D'hooghe, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	aziridine derivatives biochemical syntheses biochemical syntheses, microbiological syntheses furan derivatives mechanochemistry microbiological syntheses microwave chemistry microwave chemistry, sonochemistry, mechanochemistry pyrrole derivatives ring contraction ring expansion sonochemistry
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Beschreibung
Zusammenfassung:	The title compounds (IV) are transformed into variable mixtures of 4‐[aryl(alkylamino)methyl]butyrolactones and 5‐[aryl(hydroxy)methyl]pyrrolidin‐2‐ones by KOH‐mediated hydrolysis of the cyano group, followed by ring expansion.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201527134