ChemInform Abstract: A Convenient Method for the Asymmetric Synthesis of Fluorinated α-Amino Acids from Alcohols

The presented method provides access to a broad scope of enantioenriched aliphatic, benzylic, and pyridinyl‐substituted fluorinated α‐amino acids in a Mitsunobu‐Tsunoda reaction from a readily synthesized Belokon complex of glycine and fluorinated alcohols.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemInform 2014-12, Vol.45 (49), p.no-no
Hauptverfasser:	Drouet, Fleur, Noisier, Anais F. M., Harris, Craig S., Furkert, Daniel P., Brimble, Margaret A.
Format:	Artikel
Sprache:	eng
Schlagworte:	aminocarboxylic acids (hydrazinocarboxylic acids) and esters (benzene compounds) C-C bond formation diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) enantioselective syntheses (incl. cis/trans-isomerism)
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Beschreibung
Zusammenfassung:	The presented method provides access to a broad scope of enantioenriched aliphatic, benzylic, and pyridinyl‐substituted fluorinated α‐amino acids in a Mitsunobu‐Tsunoda reaction from a readily synthesized Belokon complex of glycine and fluorinated alcohols.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201449079