ChemInform Abstract: Synthesis of 12,12a-Dihydro-7,12a-diazacyclohepta[cd]benz[g]azulen-12-one (Cyclohepta[mn]pyrrolo[2,1-c][1,4]benzodiazepin-12-one) and Evaluation of Cytotoxic Activity Against HeLa S3 Cells

The synthesis of the new title pyrrolobenzodiazepine (IV) is described, which exhibits strong cytotoxic activity against HeLa S3 cells.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemInform 2011-10, Vol.42 (43), p.no-no
Hauptverfasser:	Yoshioka, Eiko, Fujii, Hiroyuki, Murafuji, Toshihiro, Ikeda, Reiko, Konakahara, Takeo, Gunji, Takahiro, Abe, Noritaka
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer activity anticarcinogenic activity anticarcinogenic activity, anticancer activity multi-membered N-heterocycles ring closure reactions
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The synthesis of the new title pyrrolobenzodiazepine (IV) is described, which exhibits strong cytotoxic activity against HeLa S3 cells.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201143163