ChemInform Abstract: Design, Synthesis and Inhibitory Activity Against Mycobacterium tuberculosis Thymidine Monophosphate Kinase of Acyclic Nucleoside Analogues with a Distal Imidazoquinolinone

ChemInform Abstract: Design, Synthesis and Inhibitory Activity Against Mycobacterium tuberculosis Thymidine Monophosphate Kinase of Acyclic Nucleoside Analogues with a Distal Imidazoquinolinone

New acyclic analogues, structurally related to previously described acyclic nucleoside inhibitors, are synthesized via PIFA‐mediated electrocyclization of N‐methoxyureas, e.g. (V), followed by elimination of the methoxy groups by catalytic hydrogenation.

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Veröffentlicht in:ChemInform 2011-04, Vol.42 (14), p.no-no
Hauptverfasser: Familiar, Olga, Munier-Lehmann, Helene, Ainsa, Jose Antonio, Camarasa, Maria-Jose, Perez-Perez, Maria-Jesus
Format: Artikel
Sprache:eng
Schlagworte:
enzyme inhibiting activity
nucleic acids
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Beschreibung
Zusammenfassung:New acyclic analogues, structurally related to previously described acyclic nucleoside inhibitors, are synthesized via PIFA‐mediated electrocyclization of N‐methoxyureas, e.g. (V), followed by elimination of the methoxy groups by catalytic hydrogenation.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201114207