ChemInform Abstract: Design and Synthesis of 1,4-Dihydropyridine Derivatives as BACE-1 Inhibitors

ChemInform Abstract: Design and Synthesis of 1,4-Dihydropyridine Derivatives as BACE-1 Inhibitors

Using structure‐based drug design based on computer‐aided molecular docking, an isophthalamide moiety in a known BACE‐1 inhibitor is replaced by the 1,4‐dihydropyridine (DHP) skeleton with assumed enhanced permeability through the blood‐brain barrier.

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Veröffentlicht in:ChemInform 2010-10, Vol.41 (40), p.no-no
Hauptverfasser: Choi, Soo-Jeong, Cho, Joong-Heui, Im, Isak, Lee, So-Deok, Jang, Ji-Yeong, Oh, Yu-Min, Jung, Yong-Keun, Jeon, Eun-Seok, Kim, Yong-Chul
Format: Artikel
Sprache:eng
Schlagworte:
enzyme inhibiting activity
pyridine derivatives
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Zusammenfassung:Using structure‐based drug design based on computer‐aided molecular docking, an isophthalamide moiety in a known BACE‐1 inhibitor is replaced by the 1,4‐dihydropyridine (DHP) skeleton with assumed enhanced permeability through the blood‐brain barrier.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201040220