ChemInform Abstract: Highly Efficient Synthesis and Characterization of the GPR30-Selective Agonist G-1 and Related Tetrahydroquinoline Analogues

ChemInform Abstract: Highly Efficient Synthesis and Characterization of the GPR30-Selective Agonist G-1 and Related Tetrahydroquinoline Analogues

Lewis acid‐catalyzed aza‐Diels—Alder cycloaddition of an aniline derivative (I) with cyclopentadiene (II) and various aromatic bromides (III) can be carried out in a three‐component process or by two‐step method to afford GPR30‐selective antagonist G‐1 (IVa) and derivatives (IV), (VI)/(VII), (IX), (...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ChemInform 2010-09, Vol.41 (38), p.no-no
Hauptverfasser: Burai, Ritwik, Ramesh, Chinnasamy, Shorty, Marvin, Curpan, Ramona, Bologa, Cristian, Sklar, Larry A., Oprea, Tudor, Prossnitz, Eric R., Arterburn, Jeffrey B.
Format: Artikel
Sprache:eng
Schlagworte:
fused pyridine derivatives
multicomponent reactions
ring closure reactions
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Lewis acid‐catalyzed aza‐Diels—Alder cycloaddition of an aniline derivative (I) with cyclopentadiene (II) and various aromatic bromides (III) can be carried out in a three‐component process or by two‐step method to afford GPR30‐selective antagonist G‐1 (IVa) and derivatives (IV), (VI)/(VII), (IX), (XI)/(XII).
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201038164