ChemInform Abstract: Ternary Condensation of Biginelli Thiones, Chloroacetic Acid, and Aldehydes as an Effective Approach Towards Thiazolo[3,2-a]pyrimidines and 5-Arylidenethiazolidine-2,4-diones

ChemInform Abstract: Ternary Condensation of Biginelli Thiones, Chloroacetic Acid, and Aldehydes as an Effective Approach Towards Thiazolo[3,2-a]pyrimidines and 5-Arylidenethiazolidine-2,4-diones

The three‐component reaction of thiones (I) with aldehydes (II) and chloroacetic acid readily affords thiazolo[3,2‐a]pyrimidines (IV), whilst prolonged reaction times leads to the formation of hydrolysis products (V).

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Veröffentlicht in:ChemInform 2010-08, Vol.41 (34), p.no-no
Hauptverfasser: Lebedyeva, Iryna O., Povstyanoy, Mykhaylo V., Ryabitskii, Aleksey B., Povstyanoy, Vyacheslav M.
Format: Artikel
Sprache:eng
Schlagworte:
fused pyrimidine derivatives
multicomponent reactions
ring closure reactions
thiazole derivatives
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Zusammenfassung:The three‐component reaction of thiones (I) with aldehydes (II) and chloroacetic acid readily affords thiazolo[3,2‐a]pyrimidines (IV), whilst prolonged reaction times leads to the formation of hydrolysis products (V).
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201034177