ChemInform Abstract: Divergent Synthesis of 2,3,5-Substituted Thiophenes by C-H Activation/Borylation/Suzuki Coupling

ChemInform Abstract: Divergent Synthesis of 2,3,5-Substituted Thiophenes by C-H Activation/Borylation/Suzuki Coupling

Iridium‐catalyzed C‐H borylation of chlorotrimethylsilylthiophene (III) yields compound (V), the key compound in the synthetic approach to (X), a cyclooxygenase‐2 inhibitor.

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Veröffentlicht in:ChemInform 2010-08, Vol.41 (34), p.no-no
Hauptverfasser: Kallepalli, Venkata A., Sanchez, Luis, Li, Hao, Gesmundo, Nathan J., Turton, Clarissa L., Maleczka, Robert E. Jr, Smith, Milton R. III
Format: Artikel
Sprache:eng
Schlagworte:
C-C bond formation
halogenation
thiophene derivatives
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Beschreibung
Zusammenfassung:Iridium‐catalyzed C‐H borylation of chlorotrimethylsilylthiophene (III) yields compound (V), the key compound in the synthetic approach to (X), a cyclooxygenase‐2 inhibitor.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201034113