Cover Feature: sAPPα Peptide Promotes Damaged Microglia to Clear Alzheimer's Amyloid‐β via Restoring Mitochondrial Function (Chem. Eur. J. 40/2024)

Cover Feature: sAPPα Peptide Promotes Damaged Microglia to Clear Alzheimer's Amyloid‐β via Restoring Mitochondrial Function (Chem. Eur. J. 40/2024)

The function of microglia to clear amyloid β (Aβ) is critical for Alzheimer′s patients. In their Research Article (DOI: 10.1002/chem.202400870), C. Qian and co‐workers show how the soluble amyloid precursor protein α (sAPPα) effectively enhances phagocytosis and metabolism of Aβ in damaged microglia...

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Veröffentlicht in:Chemistry : a European journal 2024-07, Vol.30 (40), p.n/a
Hauptverfasser: Tang, Yingqi, Wang, Yangang, Gao, Ziran, Li, Jiayi, Zhang, Lijia, Shi, Haoting, Dong, Jingwen, Song, Shipeng, Qian, Chenggen
Format: Artikel
Sprache:eng
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Zusammenfassung:The function of microglia to clear amyloid β (Aβ) is critical for Alzheimer′s patients. In their Research Article (DOI: 10.1002/chem.202400870), C. Qian and co‐workers show how the soluble amyloid precursor protein α (sAPPα) effectively enhances phagocytosis and metabolism of Aβ in damaged microglia by restoring mitochondrial function. sAPPα exhibits promising potential as a safe therapeutic agent or drug carrier for the treatment of Alzheimer′s disease. Cover created by Yingqi Tang.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202402238